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This webinar is for internal users only.
StratNeuro Keynote Lecture: Prof. Gaia Tavosanis
Gaia Tavosanis Professor, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), University of Bonn (a NeurotechEU partner).
Prof. Tavosanis will give a Keynote Lecture at the 2022 StraNeuro Retreat, which we are allowing other Karolinska Institutet Researchers to attend virtually via this webinar.

Title: Sparse and plastic: information coding in the mushroom body calyx of Drosophila

To identify and memorize discrete but similar environmental inputs, the brain needs to distinguish between subtle differences of activity patterns in defined neuronal populations. The Kenyon cells (KCs) of the Drosophila adult mushroom body (MB) respond sparsely to complex olfactory input, a property that is thought to support stimuli discrimination in the MB. To understand how this property emerges, we investigated the role of the inhibitory anterior paired lateral (APL) neuron in the input circuit of the MB, the calyx. Within the calyx, presynaptic boutons of projection neurons (PNs) form large synaptic microglomeruli (MGs) with dendrites of postsynaptic KCs. Combining electron microscopy (EM) data analysis and in vivo calcium imaging, we show that APL, via inhibitory and reciprocal synapses targeting both PN boutons and KC dendrites, normalizes odour-evoked representations in MGs of the calyx. APL response scales with the PN input strength and is regionalized around PN input distribution. Our data indicate that the formation of a sparse code by the KCs requires APL-driven normalization of their MG postsynaptic responses. This work provides experimental insights on how inhibition shapes sensory information representation in a higher brain centre, thereby supporting stimuli discrimination and allowing for efficient associative memory formation.

Chaired by Joana Pereira, Associate Prof. at NVS, KI and scientific coordinator at KI for NeurotechEU. Joana will give a short introduction about the NeurotechEU alliance.

May 19, 2022 02:00 PM in Stockholm

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